Drug repurposing and telomere length using the Mendelian randomization method
Responsible: Chenxi Qin
Web-site(s):
Introduction
Telomeres are nucleoprotein structures comprised of a repetitive TTAGGG sequence bounded by a set of specific proteins at the end of chromosomes. Telomere length has been reported to be associated with all-cause mortality and risks of age-related conditions. This suggested telomere length as a potential anti-ageing drug target.
Drug repurposing is a cost- and time-effective way to treat new indications with approved drugs. . Mendelian randomization mimics randomized clinical trials by using germline genetic variants as a natural way of randomization. This project aims to investigate relationships between approved drugs and telomere length using Mendelian randomization.
Drug repurposing is a cost- and time-effective way to treat new indications with approved drugs. . Mendelian randomization mimics randomized clinical trials by using germline genetic variants as a natural way of randomization. This project aims to investigate relationships between approved drugs and telomere length using Mendelian randomization.
Project details
| Department of Medical Epidemiology and Biostatistics | |
| Epidemiological study | |
| 1 | |
| Not decided | |
| All data have already been collected and only need to be analyzed | |
| Ethical permit is required and exists |
Supervisor/Contact
Chenxi Qin
46-(0)76 705 58 84
chenxi.qin@ki.se